Weir, MR.; Espaillat, R. (Jun 2015). a stomach biopsy. When doctors find intestinal metaplasia, it looks like the mucosal lining of your esophagus or stomach has been replaced with intestinal lining. Bile reflux is thought to play a key role in the development of dysplasia and carcinoma in the gastric remnant. Owen DA. [QxMD MEDLINE Link]. Nausea, bilious vomiting, and other dyspeptic symptoms may also be present. Am J Surg Pathol. Reactive gastropathy is characterized, histologically, by 21: If long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) leads to reactive gastropathy, your doctor may recommend that you stop taking NSAIDs, take a lower dose, or take a different medicine for pain. Patients who had undergone gastric surgery were found to have a statistically significant increase in reflux gastritis score, gastric pH, and gastric bile acid concentration. The densities of inflammatory cells and reactive atypia were scored at squamous, cardiac and oxyntocardiac mucosa of SCJ, antrum and body. Slides were stained for caudal type homeobox 2 (CDX-2), villin, trefoil . Reflux gastritis in the intact stomach. [8]. The duodenogastric reflux results in disruption of the protective mucus barrier and direct injury to the gastric mucosa, causing backflow of hydrogen ions and epithelial damage. Figure 1 shows the changes in percent preoperative weight and food intake up to 24 weeks postoperatively. The common underlying causes of reactive gastropathy include chronic bile reflux and long-term intake of nonsteroidal anti-inflammatory drugs (NSAIDs). Although the findings are not specific, several authors claim that weight loss and a hypochromic microcytic anemia are also associated features 3. Thus, inhibition of COX by NSAIDs reduces prostaglandin synthesis, thereby diminishing mucosal blood flow and decreasing mucus and bicarbonate secretion. Chronic use of the medication may cause the cells maintaining the mucosal layer of the stomach to stop working, leading to gastric acid damage on the stomach lining. 16(4):325-41. Numerous clinical studies have demonstrated elevated levels of depressive symptoms among selected samples of patients with gastritis [1,2,3,4,5].In patients with Helicobacter pylori-induced gastritis, levels of interleukin (IL)-8 and tumour necrosis factor- are increased in the gastric mucosa and the bacterial infection indirectly activates nuclear factor kappa B (NF- B) [6,7,8]. 2005 Jun 23. Antral mucosa exhibiting the features of reactive gastropathy, including 'corkscrew-like' foveolar hyperplasia, a mucin depleted epithelium and bundles of hyperplastic smooth muscle arranged. Maguilnik, I.; Neumann, WL. "Evolving patterns in the diagnosis of reactive gastropathy: data from a prospective Central European multicenter study with proposal of a new histologic scoring system.". Thus, inhibition of COX by NSAIDs reduces prostaglandin synthesis, thereby diminishing mucosal blood flow and decreasing mucus and bicarbonate secretion.
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